Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (N-Term) Peptide

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Protein Name
  • 1300004C08Rik
  • Ube1l
  • UBE1
  • UBE1L
  • UBE1L2
  • xubc3
  • D8
  • UBA1B
  • UBE2
  • ubiquitin-like modifier activating enzyme 7
  • ubiquitin-like modifier activating enzyme 6
  • ubiquitin-activating enzyme E1-like
  • ubiquitin-conjugating enzyme E2R 2
  • Uba7
  • UBA7
  • UBA6
  • LOC567370
  • ube2r2
Protein Region
Peptide Type
Blocking Peptide (BP)
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Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq].
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Fransen, Visschedijk, van Sommeren, Fu, Franke, Festen, Stokkers, van Bodegraven, Crusius, Hommes, Zanen, de Jong, Wijmenga, van Diemen, Weersma: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

Morgan, Han, Lam, Fraser, Ferguson: "Association analysis of 3p21 with Crohn's disease in a New Zealand population." in: Human immunology, Vol. 71, Issue 6, pp. 602-9, 2010 (PubMed).

Takeuchi, Iwahara, Saeki, Sasajima, Yokosawa: "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme." in: Journal of biochemistry, Vol. 138, Issue 6, pp. 711-9, 2006 (PubMed).