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alpha-Fetoprotein (AFP) (N-Term) Peptide

Details for Product No. ABIN692242
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Protein Name
Synonyms FETA, HPAFP
Protein Region
N-Term
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN692242
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP1430a was selected from the N-term region of human AFP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name AFP
Background Alpha-fetoprotein (AFP) is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. This protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Cajaiba, Sarita-Reyes, Zambrano et al.: "Mesenchymal hamartoma of the liver associated with features of Beckwith-Wiedemann syndrome and high serum alpha-fetoprotein levels." in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, Vol. 10, Issue 3, pp. 233-8, 2007 (PubMed).

Yamashita, Forgues, Wang et al.: "EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 5, pp. 1451-61, 2008 (PubMed).

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