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Lysine (K)-Specific Demethylase 5B (KDM5B) (N-Term) Peptide

Details for Product No. ABIN692413, Supplier: Log in to see
Protein Name
  • jarid1b
  • jarid1ba
  • id:ibd5050
  • wu:fd15c05
  • cb264
  • jarid1bb
  • plu1
  • wu:fc44h11
  • zgc:85741
  • JARID1B
  • CT31
  • PLU-1
  • PLU1
  • PUT1
  • RBBP2H1A
  • 2010009J12Rik
  • 2210016I17Rik
  • AW556288
  • D1Ertd202e
  • Jarid1b
  • Plu1
  • Rb-Bp2
  • mKIAA4034
  • RGD1565602
  • lysine (K)-specific demethylase 5Ba
  • lysine (K)-specific demethylase 5Bb
  • lysine (K)-specific demethylase 5B
  • kdm5ba
  • kdm5bb
  • KDM5B
  • Kdm5b
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kim, Shin, Subramaniam, Bruinsma, Kim, Hawse, Spelsberg, Janknecht: "Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 412-6, 2010 (PubMed).

Krishnakumar, Kraus: "PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway." in: Molecular cell, Vol. 39, Issue 5, pp. 736-49, 2010 (PubMed).

Yao, Peng, Lin: "The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity." in: Biochemical and biophysical research communications, Vol. 396, Issue 2, pp. 323-8, 2010 (PubMed).

Roesch, Fukunaga-Kalabis, Schmidt, Zabierowski, Brafford, Vultur, Basu, Gimotty, Vogt, Herlyn: "A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth." in: Cell, Vol. 141, Issue 4, pp. 583-94, 2010 (PubMed).

Hayami, Yoshimatsu, Veerakumarasivam, Unoki, Iwai, Tsunoda, Field, Kelly, Neal, Yamaue, Ponder, Nakamura, Hamamoto: "Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway." in: Molecular cancer, Vol. 9, pp. 59, 2010 (PubMed).