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Lysine (K)-Specific Demethylase 5B (KDM5B) (N-Term) Peptide

Name

Lysine (K)-Specific Demethylase 5B (KDM5B)
Synonyms
PUT1, Plu1, PLU-1, Rb-Bp2, Jarid1b, AW556288, KIAA4034, RBBP2H1A, mKIAA4034, D1Ertd202e, 2010009J12Rik, 2210016I17Rik, RGD1565602, jarid1b, jarid1ba, id:ibd5050, wu:fd15c05, plu1, cb264, zgc:85741, JA ... show more
Binding Site

N-Term
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN692413
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for JARID1B (N-term) antibody ABIN658397
Comments

Background: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Synonyms PUT1, Plu1, PLU-1, Rb-Bp2, Jarid1b, AW556288, KIAA4034, RBBP2H1A, mKIAA4034, D1Ertd202e, 2010009J12Rik, 2210016I17Rik, RGD1565602, jarid1b, jarid1ba, id:ibd5050, wu:fd15c05, plu1, cb264, zgc:85741, JARID1B

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Hayami, Yoshimatsu, Veerakumarasivam et al.: "Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway." in: Molecular cancer, Vol. 9, pp. 59, 2010 (PubMed).

Yao, Peng, Lin: "The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity." in: Biochemical and biophysical research communications, Vol. 396, Issue 2, pp. 323-8, 2010 (PubMed).

Roesch, Fukunaga-Kalabis, Schmidt et al.: "A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth." in: Cell, Vol. 141, Issue 4, pp. 583-94, 2010 (PubMed).

Krishnakumar, Kraus: "PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway." in: Molecular cell, Vol. 39, Issue 5, pp. 736-49, 2010 (PubMed).

Kim, Shin, Subramaniam et al.: "Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 412-6, 2010 (PubMed).