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Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) (N-Term) Peptide

Details for Product No. ABIN692440
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Protein Name
Synonyms fb14c08, fj51c03, zgc:85707, wu:fb14c08, wu:fj51c03, Xspred1, Xtspred1, 5730461F13Rik, AL024345, AW047647, NFLS, hSpred1, spred-1
Protein Region
N-Term
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN692440
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP1449d was selected from the N-term region of human SPRED1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name SPRED1
Background SPRED1 is a tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Yoshida, Hisamoto, Akiba et al.: "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors." in: Oncogene, Vol. 25, Issue 45, pp. 6056-66, 2006 (PubMed).

Brems, Chmara, Sahbatou et al.: "Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype." in: Nature genetics, Vol. 39, Issue 9, pp. 1120-6, 2007 (PubMed).

Validation Images
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