Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) (N-Term) Peptide

Details for Product No. ABIN692440, Supplier: Log in to see
Protein Name
  • fb14c08
  • fj51c03
  • zgc:85707
  • wu:fb14c08
  • wu:fj51c03
  • Xspred1
  • Xtspred1
  • 5730461F13Rik
  • AL024345
  • AW047647
  • NFLS
  • hSpred1
  • spred-1
  • sprouty-related, EVH1 domain containing 1
  • SPRED1
  • sprouty protein with EVH-1 domain 1, related sequence
  • spred1
  • SPRED1
  • Bm1_51610
  • Spred1
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP1449d was selected from the N-term region of human SPRED1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background SPRED1 is a tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Brems, Chmara, Sahbatou, Denayer, Taniguchi, Kato, Somers, Messiaen, De Schepper, Fryns, Cools, Marynen, Thomas, Yoshimura, Legius: "Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype." in: Nature genetics, Vol. 39, Issue 9, pp. 1120-6, 2007 (PubMed).

Yoshida, Hisamoto, Akiba, Koga, Nakamura, Tokunaga, Hanada, Kumemura, Maeyama, Harada, Ogata, Yano, Kojiro, Ueno, Yoshimura, Sata: "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors." in: Oncogene, Vol. 25, Issue 45, pp. 6056-66, 2006 (PubMed).