U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) (N-Term) Peptide

Details for Product No. ABIN692528, Supplier: Log in to see
Protein Name
  • u2af65
  • U2AF2
  • DDBDRAFT_0186947
  • DDBDRAFT_0233353
  • DDB_0186947
  • DDB_0233353
  • 65kDa
  • U2AF65
  • U2 small nuclear RNA auxiliary factor 2
  • RNA recognition motif-containing protein RRM
  • Splicing factor U2AF 65 kDa subunit
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
  • u2af2
  • U2AF2
  • U2af2
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq].
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Webby, Wolf, Gromak, Dreger, Kramer, Kessler, Nielsen, Schmitz, Butler, Yates, Delahunty, Hahn, Lengeling, Mann, Proudfoot, Schofield, Böttger: "Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing." in: Science (New York, N.Y.), Vol. 325, Issue 5936, pp. 90-3, 2009 (PubMed).

Jenkins, Shen, Green, Kielkopf: "Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33641-9, 2008 (PubMed).

Izquierdo: "Fas splicing regulation during early apoptosis is linked to caspase-mediated cleavage of U2AF65." in: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3299-307, 2008 (PubMed).