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Transcriptional Adaptor 3 (TADA3) (C-Term) Peptide

Details for Product No. ABIN692723, Supplier: Log in to see
Protein Name
  • ada3
  • ada3-B
  • ngg1
  • tada3l
  • tada3l-B
  • TADA3L
  • ADA3
  • NGG1
  • STAF54
  • hADA3
  • 1110004B19Rik
  • AI987856
  • Tada3l
  • fa03f04
  • tada3
  • wu:fa03f04
  • zgc:63596
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq].
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Hu, Ye, Lu et al.: "HPV16 E6-induced and E6AP-dependent inhibition of the transcriptional coactivator hADA3 in human cervical carcinoma cells." in: Cancer investigation, Vol. 27, Issue 3, pp. 298-306, 2009 (PubMed).

Wang, Faiola, Xu et al.: "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein." in: The Journal of biological chemistry, Vol. 283, Issue 49, pp. 33808-15, 2008 (PubMed).