Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (C-Term) Peptide

Details for Product No. ABIN692846, Supplier: Log in to see
Protein Name
  • ICOSLG
  • AU044799
  • B7-H2
  • B7RP-1
  • B7h
  • BG071784
  • GI50
  • GL50
  • GL50-B
  • ICOS-L
  • Icoslg
  • LICOS
  • Ly115l
  • mKIAA0653
  • B7H2
  • B7RP1
  • CD275
  • ICOSL
  • Icosl
  • RGD1562791
  • inducible T-cell co-stimulator ligand
  • icos ligand
  • ICOSLG
  • Icosl
  • Icoslg
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Pan, Yang, Chen, Chen, Gao, Liu, Pei, Sha, Jiang, Xu, Recker, Deng: "Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function." in: Immunogenetics, Vol. 62, Issue 4, pp. 237-51, 2010 (PubMed).

Dubois, Trynka, Franke, Hunt, Romanos, Curtotti, Zhernakova, Heap, Adány, Aromaa, Bardella, van den Berg, Bockett, de la Concha, Dema, Fehrmann, Fernández-Arquero, Fiatal, Grandone, Green, Groen et al.: "Multiple common variants for celiac disease influencing immune gene expression. ..." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).