TPX2, Microtubule-Associated Protein Homolog (Xenopus Laevis) (TPX2) Peptide

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Protein Name
  • DSAP1
  • P100
  • RP11-13G14
  • TIP110
  • p110
  • p110(nrb)
  • 2610005B21Rik
  • DIL2
  • REPP86
  • p100
  • squamous cell carcinoma antigen recognized by T cells 3
  • TPX2, microtubule-associated protein homolog (Xenopus laevis)
  • SART3
  • Tpx2
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequences used to generate the antibody AP2044a was selected from the C-terminal region with phenylalanine at position 624, C-terminal region with serine at position 729, and center region of human p100. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background The nuclear protein p100 is a proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M. Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. The full-length cDNA encodes a 747-amino acid protein with a putative ATP/GTP-binding site motif. RT-PCR analysis demonstrated strong expression of in lung carcinoma cell lines but not in normal lung tissues. Expression was also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney. P100 is also correlated to cancer prognosis.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Heidebrecht, Adam-Klages, Szczepanowski, Pollmann, Buck, Endl, Kruse, Rudolph, Parwaresch: "repp86: A human protein associated in the progression of mitosis." in: Molecular cancer research : MCR, Vol. 1, Issue 4, pp. 271-9, 2003 (PubMed).

Kufer, Silljé, Körner, Gruss, Meraldi, Nigg: "Human TPX2 is required for targeting Aurora-A kinase to the spindle." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 617-23, 2002 (PubMed).