Ring Finger Protein 216 (RNF216) (N-Term) Peptide
| Name |
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| Synonyms |
ZIN, U7I1, TRIAD3, UBCE7IP1, RNF216, UIP83, C86502, AI647468, AU019462, Ubce7ip1, 2810055G22Rik, F830018F18Rik, zin, u7i1, triad3, ubce7ip1, MGC147026, 2810055g22rik |
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Binding Site
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N-Term
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| Catalog no. |
ABIN693274 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for UBCE7IP1 (N-term) antibody ABIN388832
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Specificity
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The synthetic peptide sequence used to generate the antibody AP2106a was selected from the N-term region of human UBCE7IP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: UBCE7IP1 might act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. It inhibits TNF and IL-1 mediated activation of NF-kappa-B, and promotes TNF and RIP mediated apoptosis. Evidence exists to suggest an interaction with UBE2L3 and RIPK1. Expression is ubiquitous, with the highest levels in testis and peripheral blood leukocytes. Structurally, the protein contains a putative 1 IBR-type zinc finger and 2 RING-type zinc fingers.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Chen, Li, Zhai et al.: "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15985-91, 2002 (PubMed).
Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
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Alternatives for antigen "Ring Finger Protein 216 (RNF216)", type "Peptides"
2013 BioMed Central Research Awards
