Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) (C-Term) Peptide

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Protein Name
  • e2(17)kb1
  • sft
  • ubc4/5
  • ubch5
  • ubch5a
  • E2(17)KB1
  • SFT
  • UBC4/5
  • UBCH5
  • UBCH5A
  • ube2d1
  • wu:fc16h06
  • zgc:73096
  • ubiquitin-conjugating enzyme E2D 1
  • ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
  • ubiquitin-conjugating enzyme E2D 1b
  • UBE2D1
  • ube2d1
  • LOC100341090
  • LOC100355225
  • Ube2d1
  • ube2d1b
Protein Region
Peptide Type
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP2112b was selected from the C-term region of human UBE2D1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Brès, Kiernan, Linares, Chable-Bessia, Plechakova, Tréand, Emiliani, Peloponese, Jeang, Coux, Scheffner, Benkirane: "A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter." in: Nature cell biology, Vol. 5, Issue 8, pp. 754-61, 2003 (PubMed).

Gehrke, Riedel, Herrmann, Hadaschik, Bents, Veltkamp, Stremmel: "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis." in: Blood, Vol. 101, Issue 8, pp. 3288-93, 2003 (PubMed).

Kamura, Sato, Iwai, Czyzyk-Krzeska, Conaway, Conaway: "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 19, pp. 10430-5, 2000 (PubMed).

Jensen, Bates, Yang, Vierstra, Weissman: "Identification of a family of closely related human ubiquitin conjugating enzymes." in: The Journal of biological chemistry, Vol. 270, Issue 51, pp. 30408-14, 1996 (PubMed).