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Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) (C-Term) Peptide

Name

Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1)
Synonyms SFT, UBCH5, UBC4/5, UBCH5A, E2(17)KB1, MGC28550, zgc:73096, wu:fc16h06, sft, ubch5, ubc4/5, ubch5a, e2(17)kb1, UBE2D1, MGC134214, MGC147208
Binding Site

C-Term
4 references available
Certificates ISO 9001:2008
Catalog no. ABIN693284
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for UBE2D1 (C-term) antibody ABIN388843
Specificity The synthetic peptide sequence used to generate the antibody AP2112b was selected from the C-term region of human UBE2D1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Jensen, Bates, Yang et al.: "Identification of a family of closely related human ubiquitin conjugating enzymes." in: The Journal of biological chemistry, Vol. 270, Issue 51, pp. 30408-14, 1996 (PubMed).

Kamura, Sato, Iwai et al.: "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 19, pp. 10430-5, 2000 (PubMed).

Gehrke, Riedel, Herrmann et al.: "UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis." in: Blood, Vol. 101, Issue 8, pp. 3288-93, 2003 (PubMed).

Brès, Kiernan, Linares et al.: "A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter." in: Nature cell biology, Vol. 5, Issue 8, pp. 754-61, 2003 (PubMed).