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Ubiquitin-Conjugating Enzyme E2B (UBE2B) (C-Term) Peptide

Details for Product No. ABIN693289, Supplier: Log in to see
Protein Name
  • fc79h10
  • wu:fc79h10
  • zgc:100921
  • e2-17kda
  • hhr6b
  • hr6b
  • rad6b
  • ubc2
  • E2-17kDa
  • HHR6B
  • HR6B
  • RAD6B
  • UBC2
  • 2610301N02Rik
  • E2-14k
  • Rad6b
  • mHR6B
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
Supplier
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Specificity The synthetic peptide sequence used to generate the antibody AP2115b was selected from the C-term region of human UBE2B . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2B is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Schneider, Eckerskorn, Lottspeich et al.: "The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6." in: The EMBO journal, Vol. 9, Issue 5, pp. 1431-5, 1990 (PubMed).

Koken, Reynolds, Jaspers-Dekker et al.: "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 8865-9, 1991 (PubMed).

Koken, Smit, Jaspers-Dekker et al.: "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31." in: Genomics, Vol. 12, Issue 3, pp. 447-53, 1992 (PubMed).