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Heat Shock Factor Protein 1 (HSF1) (Sumoylation Site) Peptide

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Protein Name
Protein Region
Sumoylation Site
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP2501a is PLVRVKEEPPSPPQSPR, containing a predicted sumoylation site from the central region of human HSF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress, HSF1 acquires DNA-binding ability and localizes to nuclear stress granules. SUMO modification of HSF1 converts HSF1 to the DNA-binding form. HSF1 colocalizes with SUMO-1 in nuclear stress granules, which is prevented by mutation of the HSF1 lysine targeted for sumoylation.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Wang, Grammatikakis, Siganou et al.: "Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1." in: Molecular and cellular biology, Vol. 23, Issue 17, pp. 6013-26, 2003 (PubMed).

Catalog No. ABIN693484

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