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Peptides
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HSF2 (Sumoylation Site) Peptide
HSF2 (Sumoylation Site) Peptide
| Name |
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Binding Site
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Sumoylation Site
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| Catalog no. |
ABIN693485 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for HSF2 Sumoylation Site antibody ABIN389070
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Specificity
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The synthetic peptide sequence used to generate the antibody AP2502a was selected from the region of a human HSF2 sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: HSF2 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. The protein is found as a DNA-binding homotrimer in stressed or heat shocked cells, and otherwise found as a homodimer. HSF2 is cytoplasmic during normal growth and moves to the nucleus upon activation. Sumoylation of HSF2 hinders HSF2 DNA-binding activity, without affecting its oligomerization, and is an example of negative regulation of gene expression via sumoylation.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Schuetz, Gallo, Sheldon et al.: "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 16, pp. 6911-5, 1991 (PubMed).
He, Soncin, Grammatikakis et al.: "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress." in: The Journal of biological chemistry, Vol. 278, Issue 37, pp. 35465-75, 2003 (PubMed).
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Alternatives for antigen "HSF2", type "Peptides"
2013 BioMed Central Research Awards
