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Peptides
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SUMO1 Activating Enzyme Subunit 1 (SAE1) (N-Term) Peptide
SUMO1 Activating Enzyme Subunit 1 (SAE1) (N-Term) Peptide
| Name |
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| Synonyms |
AOS1, SUA1, UBLE1A, FLJ3091, HSPC140 |
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Binding Site
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N-Term
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| Catalog no. |
ABIN693494 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for AOS1 (N-term) antibody ABIN389080
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Specificity
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The synthetic peptide sequence used to generate the antibody AP2511a was selected from the N-terminal region of human AOS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: The dimeric enzyme AOS1 acts as a an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Okuma, Honda, Ichikawa et al.: "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2." in: Biochemical and biophysical research communications, Vol. 254, Issue 3, pp. 693-8, 1999 (PubMed).
Desterro, Rodriguez, Kemp et al.: "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 10618-24, 1999 (PubMed).
Gong, Li, Millas et al.: "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex." in: FEBS letters, Vol. 448, Issue 1, pp. 185-9, 1999 (PubMed).
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Alternatives for antigen "SUMO1 Activating Enzyme Subunit 1 (SAE1)", type "Peptides"
2013 BioMed Central Research Awards
