SUMO1 Activating Enzyme Subunit 1 (SAE1) (C-Term) Peptide

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Protein Name
  • AOS1
  • CDGAP
  • HSPC140
  • SUA1
  • UBLE1A
  • 2400010M20Rik
  • 2610044L12Rik
  • AL033372
  • AW743391
  • D7Ertd177e
  • Sua1
  • Uble1a
  • Aos1p
  • Sua1p
  • aos
  • Rho GTPase activating protein 31
  • SUMO1 activating enzyme subunit 1
  • ARHGAP31
  • SAE1
  • Sae1
  • sae1
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP2511b was selected from the C-term region of human AOS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background The dimeric enzyme AOS1 acts as a an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Desterro, Rodriguez, Kemp, Hay: "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1." in: The Journal of biological chemistry, Vol. 274, Issue 15, pp. 10618-24, 1999 (PubMed).

Gong, Li, Millas, Yeh: "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex." in: FEBS letters, Vol. 448, Issue 1, pp. 185-9, 1999 (PubMed).

Okuma, Honda, Ichikawa, Tsumagari, Yasuda: "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2." in: Biochemical and biophysical research communications, Vol. 254, Issue 3, pp. 693-8, 1999 (PubMed).