|+1 404 474 4654|
|+1 888 205 9894 (TF)|
helicase 2, X-linked (ATRX) (C-Term) Peptide
|Synonyms||SHS, XH2, XNP, ATR2, SFM1, RAD54, MRXHF1, RAD54L, ZNF-HX, MGC2094|
|3 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for ATRX (C-term) antibody ABIN389121|
|Specificity||The synthetic peptide sequence used to generate the antibody AP2541c was selected from the C-term region of human ATRX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Steensma, Higgs, Fisher et al.: "Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations." in: Blood, Vol. 103, Issue 6, pp. 2019-26, 2004 (PubMed).
Tang, Wu, Liu et al.: "A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 20369-77, 2004 (PubMed).
Mazina, Mazin: "Human Rad54 protein stimulates DNA strand exchange activity of hRad51 protein in the presence of Ca2+." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52042-51, 2004 (PubMed).