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helicase 2, X-linked (ATRX) (C-Term) Peptide

Name

helicase 2, X-linked (ATRX)
Synonyms SHS, XH2, XNP, ATR2, SFM1, RAD54, MRXHF1, RAD54L, ZNF-HX, MGC2094
Binding Site

C-Term
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN693531
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for ATRX (C-term) antibody ABIN389121
Specificity The synthetic peptide sequence used to generate the antibody AP2541c was selected from the C-term region of human ATRX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. Theses mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Steensma, Higgs, Fisher et al.: "Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations." in: Blood, Vol. 103, Issue 6, pp. 2019-26, 2004 (PubMed).

Tang, Wu, Liu et al.: "A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 20369-77, 2004 (PubMed).

Mazina, Mazin: "Human Rad54 protein stimulates DNA strand exchange activity of hRad51 protein in the presence of Ca2+." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52042-51, 2004 (PubMed).