tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, theta Polypeptide (YWHAQ) (pThr232) Peptide

Details for Product No. ABIN693925
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Protein Name
Synonyms 1C5, HS1, 14-3-3, 2700028P07Rik, AA409740, AU021156, R74690, 14-3-3t, 1c5, hs1
Protein Region
pThr232
Application
Blocking Peptide (BP)
Pubmed 4 references available
Catalog no. ABIN693925
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP3001a was selected from the region of human Phospho-14-3-3-T232. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name 14-3-3
Background The 14-3-3 family of proteins mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.
Comment

Background: The 14-3-3 family of proteins mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Clark, Oelke, Johnson et al.: "CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 19401-6, 2004 (PubMed).

Wang, Grammatikakis, Siganou et al.: "Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49460-9, 2004 (PubMed).

Urschel, Bassermann, Bai et al.: "Phosphorylation of grb10 regulates its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 16987-93, 2005 (PubMed).

Yanagi, Shirakawa, Kitamura et al.: "Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese." in: Journal of human genetics, Vol. 50, Issue 4, pp. 210-6, 2005 (PubMed).

Reactivities (1), (1), (1), (1)
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