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cJun (pSer73) Peptide
|5 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for Phospho-cJun-S73 antibody ABIN389546|
|Specificity||The synthetic peptide sequence used to generate the antibody AP3075a was selected from the region of human Phospho-cJun-S73. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: The gene for cJun is the putative transforming gene of avian sarcoma virus 17. The cJun protein is a transcription factor highly similar to the viral protein, and interacts directly with specific target DNA sequences to regulate gene expression. The gene maps to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Bianchi, Denti, Catena et al.: "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 19682-90, 2003 (PubMed).
Zerbini, Wang, Cho et al.: "Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer." in: Cancer research, Vol. 63, Issue 9, pp. 2206-15, 2003 (PubMed).
Kim, Lee, Cho et al.: "Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex." in: Cancer research, Vol. 63, Issue 19, pp. 6135-9, 2003 (PubMed).
Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).
Naito, Kaji, Sowa et al.: "Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4785-91, 2005 (PubMed).