Death-Domain Associated Protein (DAXX) (pSer671) Peptide

Details for Product No. ABIN694237
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Protein Name
Synonyms im:6905684, LOC100226911, BING2, DAP6, EAP1
Protein Region
pSer671
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN694237
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP3532a was selected from the region of human Phospho-DAXX-pS671. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name DAXX
Background DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).

Gostissa, Morelli, Mantovani et al.: "The transcriptional repressor hDaxx potentiates p53-dependent apoptosis." in: The Journal of biological chemistry, Vol. 279, Issue 46, pp. 48013-23, 2004 (PubMed).

Chang, Lin, Fang et al.: "Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4." in: The Journal of biological chemistry, Vol. 280, Issue 11, pp. 10164-73, 2005 (PubMed).

Greger, Katz, Ishov et al.: "The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription." in: Journal of virology, Vol. 79, Issue 8, pp. 4610-8, 2005 (PubMed).

Cantrell, Bresnahan: "Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replication." in: Journal of virology, Vol. 79, Issue 12, pp. 7792-802, 2005 (PubMed).

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