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tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr518) Peptide

Name

tyrosine Kinase, Non-Receptor, 2 (TNK2)
Binding Site

pTyr518
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN694287
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for Phospho-ACK1-pY518 antibody ABIN389970
Specificity The synthetic peptide sequence used to generate the antibody AP3587a was selected from the region of human Phospho-ACK1-pY518. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Goss, Lee, Moritz et al.: "A common phosphotyrosine signature for the Bcr-Abl kinase." in: Blood, Vol. 107, Issue 12, pp. 4888-97, 2006 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Huang, Mukasa, Bonavia et al.: "Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 31, pp. 12867-72, 2007 (PubMed).

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Alternatives for antigen "tyrosine Kinase, Non-Receptor, 2 (TNK2)", type "Peptides"
Reactivities Human (2), Mouse (Murine) (2)