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Lin-28 Homolog A (C. Elegans) (LIN28A) (pSer86) Peptide

Name

Lin-28 Homolog A (C. Elegans) (LIN28A)
Synonyms CSDD1, LIN28, LIN-28, ZCCHC1, FLJ12457, Lin28, Tex17, Lin-28, Gm10299, AL024421, ENSMUSG00000070700, csdd1, lin-28, lin28a, zcchc1, lin28, MGC55584, sb:cb650, zgc:55584, RGD1566408, MGC97527
Binding Site

pSer86
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN694344
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for Phospho-LIN28-S86 antibody ABIN390036
Specificity The synthetic peptide sequence used to generate the antibody AP3653a was selected from the region of human Phospho-LIN28-S86. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: LIN28A acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. It is essential for skeletal muscle differentiation through the translational up-regulation of IGF2 expression.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Piskounova, Viswanathan, Janas et al.: "Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28." in: The Journal of biological chemistry, Vol. 283, Issue 31, pp. 21310-4, 2008 (PubMed).