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Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) (pSer32, pSer36) Peptide

Name

Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA)
Synonyms IKBA, MAD-3, NFKBI
Binding Site

pSer32, pSer36
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN694352
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for Phospho-NFKBIA-S32/36 antibody ABIN650807
Specificity The synthetic peptide sequence used to generate the antibody AP3666a was selected from the region of human Phospho-NFKBIA-S32/36. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Shimada, Kawai, Takeda et al.: "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases." in: International immunology, Vol. 11, Issue 8, pp. 1357-62, 1999 (PubMed).

Gil, Alcamí, Esteban: "Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex." in: Oncogene, Vol. 19, Issue 11, pp. 1369-78, 2000 (PubMed).