Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (cleaved), (Asp175) Peptide

Details for Product No. ABIN694398
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Protein Name
Protein Region
cleaved, Asp175
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 1 reference available
Quantity 0.1 mg
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Immunogen Synthetic peptide
Alternative Name CASP3
Background CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Mei, Yong, Liu et al.: "tRNA binds to cytochrome c and inhibits caspase activation." in: Molecular cell, Vol. 37, Issue 5, pp. 668-78, 2010 (PubMed).

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Catalog No. ABIN694398
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