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Actin-Like 6B (ACTL6B) (N-Term) Peptide

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Protein Name
Protein Region
Peptide Type Synthetic
Blocking Peptide (BP)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Synthetic peptide
Background ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila, the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Oma, Nishimori, Harata: "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP." in: Biochemical and biophysical research communications, Vol. 301, Issue 2, pp. 521-8, 2003 (PubMed).

Kuroda, Oma, Nishimori et al.: "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex." in: Biochemical and biophysical research communications, Vol. 299, Issue 2, pp. 328-34, 2002 (PubMed).

Olave, Wang, Xue et al.: "Identification of a polymorphic, neuron-specific chromatin remodeling complex." in: Genes & development, Vol. 16, Issue 19, pp. 2509-17, 2002 (PubMed).

Catalog No. ABIN695016

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