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Details for Product No. ABIN695016

Actin-Like 6B (ACTL6B) (N-Term) Peptide

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Protein Name
Synonyms ACTL6, BAF53B, Actl6, ArpNa, Baf53b, MGC110167, zgc:110167
Protein Region
N-Term
Application
Blocking Peptide (BP)
Pubmed 3 references available
Catalog no. ABIN695016
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Alternative Name ACTL6B
Background ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila, the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
Comment

Background: ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila, the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Olave, Wang, Xue et al.: "Identification of a polymorphic, neuron-specific chromatin remodeling complex." in: Genes & development, Vol. 16, Issue 19, pp. 2509-17, 2002 (PubMed).

Kuroda, Oma, Nishimori et al.: "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex." in: Biochemical and biophysical research communications, Vol. 299, Issue 2, pp. 328-34, 2002 (PubMed).

Oma, Nishimori, Harata: "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP." in: Biochemical and biophysical research communications, Vol. 301, Issue 2, pp. 521-8, 2003 (PubMed).

Alternatives for antigen "Actin-Like 6B (ACTL6B)", type "Peptides"
Reactivities (1), (1), (1), (1), (1), (1)
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