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D-Amino Acid Oxidase Activator (DAOA) (C-Term) Peptide

Details for Product No. ABIN695258, Supplier: Log in to see
Protein Name
  • daao
  • damox
  • DAO
  • DKFZp469N2232
  • LG72
  • MGC114783
  • oxda
  • SG72
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
Supplier
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Background DAOA is a protein that is an activator of the FAD-dependent enzyme D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder, possibly due to decreased levels of D-serine and decreased NMDA receptor functioning.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Schumacher, Jamra, Freudenberg, Becker, Ohlraun, Otte, Tullius, Kovalenko, Bogaert, Maier, Rietschel, Propping, Nöthen, Cichon: "Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder." in: Molecular psychiatry, Vol. 9, Issue 2, pp. 203-7, 2004 (PubMed).

Hattori, Liu, Badner, Bonner, Christian, Maheshwari, Detera-Wadleigh, Gibbs, Gershon: "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series." in: American journal of human genetics, Vol. 72, Issue 5, pp. 1131-40, 2003 (PubMed).

Chumakov, Blumenfeld, Guerassimenko, Cavarec, Palicio, Abderrahim, Bougueleret, Barry, Tanaka, La Rosa, Puech, Tahri, Cohen-Akenine, Delabrosse, Lissarrague, Picard, Maurice, Essioux, Millasseau, Grel, Debailleul, Simon, Caterina, Dufaure, Malekzadeh, Bel: "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13675-80, 2002 (PubMed).