ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) (C-Term) Peptide

Details for Product No. ABIN695581
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Protein Name
Synonyms BSEP, PGY4, SPGP, ABC16, BRIC2, PFIC2, PFIC-2, Bsep, Lith1, Spgp, BSEP/SPGP, ABCB11
Protein Region
C-Term
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 1 reference available
Catalog no. ABIN695581
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP6110a was selected from the C-term region of human ABCB11 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name ABCB11
Background ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Strautnieks, Bull, Knisely et al.: "A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis." in: Nature genetics, Vol. 20, Issue 3, pp. 233-8, 1998 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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