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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) (C-Term) Peptide

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Protein Name
  • ABCB11
  • Bsep
  • ABC16
  • BRIC2
  • BSEP
  • PFIC-2
  • PFIC2
  • PGY4
  • SPGP
  • Lith1
  • BSEP/SPGP
  • Spgp
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11
  • bile salt export pump
  • ATP-binding cassette, subfamily B (MDR/TAP), member 11
  • ABCB11
  • abcb11
  • EDI_111220
  • EDI_272930
  • Abcb11
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP6110a was selected from the C-term region of human ABCB11 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Strautnieks, Bull, Knisely, Kocoshis, Dahl, Arnell, Sokal, Dahan, Childs, Ling, Tanner, Kagalwalla, Németh, Pawlowska, Baker, Mieli-Vergani, Freimer, Gardiner, Thompson: "A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis." in: Nature genetics, Vol. 20, Issue 3, pp. 233-8, 1998 (PubMed).