ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) (C-Term) Peptide

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Protein Name
Protein Region
C-Term
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 5 references available
Quantity 0.1 mg
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP6114a was selected from the C-term region of human ABCB7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name ABCB7
Background The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Allikmets, Raskind, Hutchinson et al.: "Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)." in: Human molecular genetics, Vol. 8, Issue 5, pp. 743-9, 1999 (PubMed).

Csere, Lill, Kispal: "Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p." in: FEBS letters, Vol. 441, Issue 2, pp. 266-70, 1999 (PubMed).

Mao, Fu, Wu et al.: "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 8175-80, 1998 (PubMed).

Shimada, Okuno, Kawai et al.: "Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia." in: Journal of human genetics, Vol. 43, Issue 2, pp. 115-22, 1998 (PubMed).

Savary, Allikmets, Denizot et al.: "Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human." in: Genomics, Vol. 41, Issue 2, pp. 275-8, 1997 (PubMed).

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