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MAFK (C-Term) Peptide

Details for Product No. ABIN695662
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Protein Name
Synonyms NFE2U, P18, AW061068, NF-E2, Nfe2u
Protein Region
C-Term
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN695662
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP6215a was selected from the C-term region of human MAFK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background The maf oncogene was identified by structural analysis of the AS42 avian transforming retrovirus genome. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Both subclasses contain leucinezipper motifs, which allow homodimerization as well as heterodimerization with a variety of other bZip transcription factors. Large Mafs also contain an acidic transactivation domain absent in the small Maf proteins. Although they do not possess inherent transactivation activity, small Maf proteins can act as positive regulators of transcription by targeting transcriptionally active dimerization partners to specific DNA regulatory elements. Conversely, small Mafs can act also as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can replace active dimers. Human MafF was isolated in a yeast one-hybrid system from a human myometrium cDNA library. Human MAFF encodes a 164 amino acids proten. Like other small MAFF proteins, it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. The three small Maf proteins have been implicated in a number of physiological processes, including development, differentiation, haematopoiesis and stress response. Interestingly, these three proteins regulate the stress response via different mechanisms.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Osaka, Rowley, Zeleznik-Le: "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6428-33, 1999 (PubMed).

Russell, McIlhatton, Burrows et al.: "Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors." in: Cancer research, Vol. 60, Issue 17, pp. 4729-34, 2000 (PubMed).

McIlhatton, Burrows, Donaghy et al.: "Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3." in: Oncogene, Vol. 20, Issue 41, pp. 5930-9, 2001 (PubMed).

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