|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term,Pro222) Peptide
|Synonyms||ABAD, CAMR, ERAB, HCD2, MHBD, HADH2, MRPP2, MRX17, MRX31, SCHAD, MRXS10, SDR5C1, 17b-HSD10, DUPXp11.22, HSD17, SDR9C2, EDH17B2, HSD17B10, MGC134122, hadh2, im:6899159, wu:fj61f03, zgc:101605, Hadh2|
|2 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for HADH2 (C-term P222) antibody ABIN390287|
|Specificity||The synthetic peptide sequence used to generate the antibody AP6307c was selected from the C-term region of human HADH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases, unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
He, Merz, Mehta et al.: "Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 15014-9, 1999 (PubMed).
Takuma, Yao, Huang et al.: "ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, Issue 6, pp. 597-8, 2005 (PubMed).