|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Voltage-Dependent Anion Channel 1 (VDAC1) (N-Term) Peptide
|Synonyms||PORIN, MGC111064, PORIN-31-HL, Vdac5, AL033343, fa13f11, zgc:85830, wu:fa13f11, MGC53435, vdac1, VDAC1|
|2 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for VDAC1 (N-term) antibody ABIN390563|
|Specificity||The synthetic peptide sequence used to generate the antibody AP6627a was selected from the N-term region of human VDAC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Hiller, Garces, Malia et al.: "Solution structure of the integral human membrane protein VDAC-1 in detergent micelles." in: Science (New York, N.Y.), Vol. 321, Issue 5893, pp. 1206-10, 2008 (PubMed).
Shoshan-Barmatz, Zakar, Rosenthal et al.: "Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase." in: Biochimica et biophysica acta, Vol. 1787, Issue 5, pp. 421-30, 2009 (PubMed).