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Voltage-Dependent Anion Channel 1 (VDAC1) (Center) Peptide

Details for Product No. ABIN696031, Supplier: Log in to see
Protein Name
  • vdac1
  • VDAC1
  • 5076
  • T22N4.9
  • T22N4_9
  • voltage dependent anion channel 1
  • VDAC-1
  • AL033343
  • Vdac5
  • fa13f11
  • wu:fa13f11
  • zgc:85830
  • voltage-dependent anion channel 1
  • voltage dependent anion channel 1
  • vdac1
  • VDAC1
  • Vdac1
Protein Region
Peptide Type
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP6627c was selected from the Center region of human VDAC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Shoshan-Barmatz, Zakar, Rosenthal, Abu-Hamad: "Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase." in: Biochimica et biophysica acta, Vol. 1787, Issue 5, pp. 421-30, 2009 (PubMed).

Hiller, Garces, Malia, Orekhov, Colombini, Wagner: "Solution structure of the integral human membrane protein VDAC-1 in detergent micelles." in: Science (New York, N.Y.), Vol. 321, Issue 5893, pp. 1206-10, 2008 (PubMed).