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Details for Product No. ABIN696106

Exportin 1, CRM1 Homolog (Yeast) (XPO1) (C-Term) Peptide

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Protein Name
Synonyms
Xpo, crm1, exportin-1, CRM1, emb, exp1, AA420417, Crm1, Exp1, CG13387, DCRM1, Dmel\\CG13387, Emb, XPO-1, XPO1, Xpo1, dCRM1, l(2)k16715, 18.m06600, DDBDRAFT_0183812, DDBDRAFT_0234066, DDB_0183812, DDB_ ... show more
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 1 reference available
Catalog no. ABIN696106
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP6684b was selected from the C-term region of human XPO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name XPO1
Background XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Comment

Background: XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dong, Biswas, Chook: "Structural basis for assembly and disassembly of the CRM1 nuclear export complex." in: Nature structural & molecular biology, Vol. 16, Issue 5, pp. 558-60, 2009 (PubMed).

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