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Exportin 1, CRM1 Homolog (Yeast) (XPO1) (C-Term) Peptide

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Protein Name
Protein Region
C-Term
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP6684b was selected from the C-term region of human XPO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dong, Biswas, Chook: "Structural basis for assembly and disassembly of the CRM1 nuclear export complex." in: Nature structural & molecular biology, Vol. 16, Issue 5, pp. 558-60, 2009 (PubMed).

Catalog No. ABIN696106

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