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Aurora Kinase C (AURKC) (N-Term,Met1) Peptide

Name

Aurora Kinase C (AURKC)
Synonyms AIE2, AIK3, AurC, STK13, aurora-C, AIE1, Stk13, AURKC
Binding Site

N-Term,Met1
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN696469
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for Aurora-C (N-term M1) antibody ABIN390977
Specificity The synthetic peptide sequence used to generate the antibody AP7000e was selected from the N-term region of human Aurora-C . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Bernard, Sanseau, Henry et al.: "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter." in: Genomics, Vol. 53, Issue 3, pp. 406-9, 1998 (PubMed).

Tseng, Chen, Hsu et al.: "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators." in: DNA and cell biology, Vol. 17, Issue 10, pp. 823-33, 1998 (PubMed).

Kimura, Matsuda, Yoshioka et al.: "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7334-40, 1999 (PubMed).

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Alternatives for antigen "Aurora Kinase C (AURKC)", type "Peptides"
Reactivities Mouse (Murine) (1)