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Adrenergic, Beta, Receptor Kinase 2 (ADRBK2) (C-Term) Peptide

Details for Product No. ABIN696478, Supplier: Log in to see
Protein Name
  • 4833444A01Rik
  • Adrbk-2
  • AI851927
  • AW551196
  • Bark-2
  • BARK2
  • bark2
  • Grk3
  • GRK3
  • grk3
  • si:dz221d18.1
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP7005a was selected from the C-term region of human GRK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Calabrese, Sallese, Stornaiuolo, Stuppia, Palka, De Blasi: "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes." in: Genomics, Vol. 23, Issue 1, pp. 286-8, 1995 (PubMed).

Parruti, Ambrosini, Sallese, De Blasi: "Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2." in: Biochemical and biophysical research communications, Vol. 190, Issue 2, pp. 475-81, 1993 (PubMed).

Benovic, Onorato, Arriza, Stone, Lohse, Jenkins, Gilbert, Copeland, Caron, Lefkowitz: "Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family." in: The Journal of biological chemistry, Vol. 266, Issue 23, pp. 14939-46, 1991 (PubMed).