Activin A Receptor, Type IIA (ACVR2A) (N-Term) Peptide
| Name | Activin A Receptor, Type IIA (ACVR2A) |
| Synonyms | ACVR2, ACTRII, Acvr2, ActrIIa, TactrII, rActR-II, ACVR2A, acvr2a, acvr2, actr2a, wu:fa02e10, actrii |
| Binding Site |
N-Term |
 |
3 references available |
| Certificates | ISO 9001:2008 |
| Catalog no. | ABIN696631 |
| Quantity | 0.1 mg |
| Price | 49.50 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 2 to 3 Business Days |
Additional Information
| Immunogen | Synthetic peptide |
| Characteristics | Blocking peptide for ACVR2A (N-term) antibody ABIN391160 |
| Specificity | The synthetic peptide sequence used to generate the antibody AP7103a was selected from the N-term region of human ACVR2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Comments |
Background: ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. |
Application Details
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles |
| Restrictions | For Research Use only |
Publications
| Product |
Casagrandi, Bearfield, Geary et al.: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).
Greenwald, Groppe, Gray et al.: "The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly." in: Molecular cell, Vol. 11, Issue 3, pp. 605-17, 2003 (PubMed). Olaru, Mori, Yin et al.: "Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 83, Issue 12, pp. 1867-71, 2003 (PubMed). |
