Activin A Receptor, Type IIB (ACVR2B) (C-Term), (Val474) Peptide

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Protein Name
  • ACVR2B
  • XAR1
  • actr-iib
  • actriib
  • ACTRIIB
  • ActR-IIB
  • HTX4
  • ActRIIB
  • actr2b
  • actrIIb
  • wu:fj97d11
  • activin A receptor, type IIB
  • activin receptor IIb
  • activin receptor IIB
  • ACVR2B
  • acvr2b
  • Acvr2b
Protein Region
C-Term, Val474
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP7105b was selected from the C-term region of human ACVR2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor)displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Harrison, Gray, Fischer, Donaldson, Choe, Vale: "An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28036-44, 2004 (PubMed).

Martins da Silva, Bayne, Cambray, Hartley, McNeilly, Anderson: "Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation." in: Developmental biology, Vol. 266, Issue 2, pp. 334-45, 2004 (PubMed).

Casagrandi, Bearfield, Geary, Redman, Muttukrishna: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).

Shin, Wang, Yim, Le Naour, Brichory, Jang, Zhao, Puravs, Tra, Michael, Misek, Hanash: "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7607-16, 2003 (PubMed).