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Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) (C-Term) Peptide

Details for Product No. ABIN696764, Supplier: Log in to see
Protein Name
  • AI194361
  • AI450832
  • AL024255
  • AMPK
  • ampk
  • AMPK1
  • AMPKa1
  • ampka1
  • AMPKalpha1
  • C130083N04Rik
  • cb116
  • im:7154392
  • PRKAA1
  • Prkaa1
  • sb:cb130
  • wu:fa94c10
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence is selected from aa 494~510 of human AMPK alpha 1.
Background AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. AMPK alpha1, a member of the Ser/Thr protein kinase family, is a catalytic subunit of AMPK.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).