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5'-AMP-Activated Protein Kinase Catalytic Subunit alpha-1 (N-Term) Peptide
|2 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for AMPK1 (N-term) antibody ABIN391379|
|Specificity||The synthetic peptide sequence used to generate the antibody AP7255a was selected from the N-term region of human AMPK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: AMPK1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Stapleton, Mitchelhill, Gao et al.: "Mammalian AMP-activated protein kinase subfamily." in: The Journal of biological chemistry, Vol. 271, Issue 2, pp. 611-4, 1996 (PubMed).
Lizcano, Göransson, Toth et al.: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, 2004 (PubMed).