ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) (Center) Peptide

Details for Product No. ABIN697064, Supplier: Log in to see
Protein Name
  • 9530092O11Rik
  • ADAM-TS5
  • ADAMTS1
  • ADAMTS11
  • AI481094
  • ASMP-2
  • ADAM-TS 11
  • ADAM-TS 5
  • ADAMTS-11
  • ADAMTS-5
  • ADMP-2
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
  • ADAMTS5
  • adamts5
  • Adamts5
Protein Region
Center
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP7447c was selected from the Center region of human ADAMTS5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: "The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25791-7, 2000 (PubMed).

Hurskainen, Hirohata, Seldin, Apte: "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family." in: The Journal of biological chemistry, Vol. 274, Issue 36, pp. 25555-63, 1999 (PubMed).