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Mitogen-Activated Protein Kinase 10 (MAPK10) (N-Term) Peptide

Details for Product No. ABIN697152, Supplier: Log in to see
Protein Name
  • MAPK10
  • zgc:123234
  • DKFZp459H0638
  • Jnk3
  • SAPKC
  • SAPb
  • Serk2
  • JNK3
  • JNK3A
  • PRKM10
  • SAPK1b
  • p493F12
  • p54bSAPK
  • C230008H04Rik
  • JNK3B1
  • JNK3B2
  • SAPK(beta)
  • ATMPK10
  • MAP kinase 10
  • mitogen-activated protein kinase 10
  • mitogen activated protein kinase 10
  • mapk10
  • MAPK10
  • Mapk10
  • MPK10
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP7507a was selected from the N-term region of human JNK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Yoshida, Harada, Nagai, Fukino, Teramoto, Emi: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, 2002 (PubMed).

McDonald, Chow, Miller, Laporte, Field, Lin, Davis, Lefkowitz: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, 2000 (PubMed).

Yang, Kuan, Whitmarsh, Rincón, Zheng, Davis, Rakic, Flavell: "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene." in: Nature, Vol. 389, Issue 6653, pp. 865-70, 1997 (PubMed).

Gupta, Barrett, Whitmarsh, Cavanagh, Sluss, Dérijard, Davis: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, 1996 (PubMed).