|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Mitogen-Activated Protein Kinase 10 (MAPK10) (N-Term) Peptide
|Synonyms||JNK3, JNK3A, PRKM10, p493F12, FLJ12099, FLJ33785, MGC50974, p54bSAPK, MAPK10, MGC123234, zgc:123234, ATMPK10, MAP kinase 10, MPK10, DKFZp459H0638|
|4 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for JNK3 (N-term) antibody ABIN391727|
|Specificity||The synthetic peptide sequence used to generate the antibody AP7507a was selected from the N-term region of human JNK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Gupta, Barrett, Whitmarsh et al.: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, 1996 (PubMed).
Yang, Kuan, Whitmarsh et al.: "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene." in: Nature, Vol. 389, Issue 6653, pp. 865-70, 1997 (PubMed).
McDonald, Chow, Miller et al.: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, 2000 (PubMed).
Yoshida, Harada, Nagai et al.: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, 2002 (PubMed).