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GRB2-Related Adaptor Protein 2 (GRAP2) (N-Term) Peptide

Name

GRB2-Related Adaptor Protein 2 (GRAP2)
Synonyms P38, GADS, GRID, GRPL, GrbX, Mona, GRB2L, GRBLG, Grf40, GRAP-2, Gads, GrpL, MGC125066, GRAP2, zgc:112091, grap2
Binding Site

N-Term
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN697153
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for P38 (N-term) antibody ABIN391728
Specificity The synthetic peptide sequence used to generate the antibody AP7508a was selected from the N-term region of human P38 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses, changes in extracellular osmality, and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Dean, Sarsfield, Tsounakou et al.: "p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39470-6, 2003 (PubMed).

Cheung, Campbell, Nebreda et al.: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003 (PubMed).