Cyclin-Dependent Kinase 9 (CDK9) (C-Term) Peptide
| Name |
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| Synonyms |
TAK, C-2k, CTK1, CDC2L4, PITALRE, CDK9, P-TEF, P-TEFb, PTefb, DmelCG5179, CG5179, wu:fb22e09, wu:fc06c02, MGC95175, cdk9, MGC53831, MGC139578, tak, c-2k, cdc2l4, pitalre, MGC69296 |
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Binding Site
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C-Term
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| Catalog no. |
ABIN697185 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for CDK9 (C-term) antibody ABIN391760
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Specificity
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The synthetic peptide sequence used to generate the antibody AP7525b was selected from the C-term region of human CDK9 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: CDK9, a member of the CDC2/CDKX subfamily of Ser/Thr protein kinases, is a component of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The CDK9/cyclin K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFB in vitro. In vitro, this protein phosphorylates retinoblastoma and myelin basic protein.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Graña, De Luca, Sang et al.: "PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 9, pp. 3834-8, 1994 (PubMed).
Fu, Peng, Lee et al.: "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription." in: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 34527-30, 2000 (PubMed).
Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).
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Alternatives for antigen "Cyclin-Dependent Kinase 9 (CDK9)", type "Peptides"
