Acetyl-CoA Acetyltransferase 1 (ACAT1) (C-Term) Peptide

Details for Product No. ABIN697224
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Protein Name
Synonyms T2, MAT, ACAT, THIL, RATACAL, Acat, 6330585C21Rik, fd16h07, fd20g06, zgc:86832, wu:fd16h07, wu:fd20g06, acat1-a, ACAT1, Es1, Es2, LOC100009551
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 2 references available
Catalog no. ABIN697224
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP7560b was selected from the C-term region of human ACAT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name ACAT1
Background ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder,an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
Comment

Background: ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder,an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Haapalainen, Meriläinen, Pirilä et al.: "Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function." in: Biochemistry, Vol. 46, Issue 14, pp. 4305-21, 2007 (PubMed).

Guo, Chang, Chang: "Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1." in: Biochemistry, Vol. 46, Issue 35, pp. 10063-71, 2007 (PubMed).

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