E2F Transcription Factor 1 (E2F1) (Center) Peptide

Details for Product No. ABIN697273
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Protein Name
Protein Region
Center
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 2 references available
Quantity 0.1 mg
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Immunogen Synthetic peptide
Alternative Name E2F1
Background E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Paik, Wang, Liu et al.: "Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6348-63, 2010 (PubMed).

Pulikkan, Dengler, Peramangalam et al.: "Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia." in: Blood, Vol. 115, Issue 9, pp. 1768-78, 2010 (PubMed).

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Catalog No. ABIN697273
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