|+1 404 474 4654|
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Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (Center) Peptide
|Synonyms||CD246, NBLST3, TFG/ALK, Tcrz, ALK|
|3 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for ALK (Center) antibody ABIN652362|
|Specificity||The synthetic peptide sequence used to generate the antibody AP7600c was selected from the Center region of human ALK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
Background: ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2,5)(p23,q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Morris, Kirstein, Valentine et al.: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).
Iwahara, Fujimoto, Wen et al.: "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system." in: Oncogene, Vol. 14, Issue 4, pp. 439-49, 1997 (PubMed).
Morris, Naeve, Mathew et al.: "ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)" in: Oncogene, Vol. 14, Issue 18, pp. 2175-88, 1997 (PubMed).